Mastering Polymorphism
In Drug Discovery
The ability of a substance to exist in two or more crystalline forms due to the difference in packing, orientation, and conformation of atoms results in the difference in physical and chemical properties.
Understanding Polymorphic Variations & Drug Quality
The ability of a substance to exist in two or more crystalline forms due to the difference in packing, orientation, and conformation of atoms results in the difference in physical and chemical properties of that substance.
Pharmaceutical industries study these differences in the properties which may result in advantageous or deleterious consequences on the quality, efficacy, and nature of the drug.
Analyze differences in atom packing, orientation, and conformation.
Assess consequences on physical and chemical behavior of drug substances.
Prevent deleterious outcomes and leverage advantageous clinical profiles.
Collaborate with Varanous Labs for dedicated solid-state screening.
Advanced Vibrational
Spectroscopy Techniques
Varanous Labs partners you in performing these studies with the help of vibrational spectroscopies, namely Infrared and Raman, which are used to detect and characterize different polymorphic forms.
Infrared Spectroscopy (IR)
Precise vibrational detection of functional group variations and crystal lattice packing differences.
- Molecular bond vibration
- Lattice conformation
- Polymorph screening
Raman Spectroscopy
Non-destructive scattering analysis to identify and characterize distinct crystalline polymorphs.
- Scattering fingerprint
- Non-destructive testing
- Phase purity checks
Solid-State Characterization
Comprehensive evaluation of crystal habits, pseudopolymorphs, and amorphous transitions.
- Crystal habit study
- Pseudopolymorph profiling
- Amorphous content
Quality & Efficacy Assurance
Ensuring drug stability, bioavailability, and consistent performance across production batches.
- Bioavailability safety
- Stability evaluation
- Regulatory compliance
Property Profiling
Detecting advantageous or deleterious consequences of polymorphic transitions on drug nature.
- Physicochemical testing
- Transition monitoring
- Formulation safety
Partnering Your Research
With Vibrational Analysis
Varanous Labs partners you in performing these studies with the help of vibrational spectroscopies, namely Infrared and Raman, which are used to detect and characterize different polymorphic forms, safeguarding your drug quality and therapeutic efficacy.
EXPERTISE
Advantageous Outcomes
For Your Formulations
Avoiding deleterious consequences while optimizing the quality, efficacy, and safety profile of your drug.
Vibrational Mastery
Advanced Infrared and Raman spectroscopy for definitive polymorph identification.
Efficacy Protection
Screening differences that influence dissolution, stability, and bioavailability.
Rigorous Screening
Thorough evaluation of atomic packing, orientation, and conformational shifts.
Actionable Insights
Clear guidance to leverage advantageous crystal forms in drug development.
A Systematic Path to Polymorph Analysis
Structured workflow to detect, characterize, and evaluate polymorphic variations in drug substances.
Sample Intake
Receive drug substance samples and establish baseline physical parameters.
IR Spectroscopy
Perform Infrared analysis to detect unique molecular vibrational modes.
Raman Analysis
Examine scattering spectra for crystal lattice orientation differences.
Characterization
Differentiate polymorphic forms and assess property impacts.
Expert Report
Deliver comprehensive data to secure product quality and efficacy.
Ready to Conduct Polymorphism Studies
& Vibrational Analysis for Your Drug?
Partner with Varanous Labs to detect and characterize polymorphic forms using advanced Infrared and Raman spectroscopies.